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Original Research Article | OPEN ACCESS

Protective effect of punicalagin against intracerebral haemorrhage via improvement in blood-brain barrier integrity, and suppression of reactive oxygen species and NF-κB-mediated NLRP3 inflammasome

Darong Wu1, Bo Li2

1Department of Neurology, Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong 518116; 2Department of Neurology, Guangdong 999Brain Hospital, Guangzhou, Guangdong 510510, China.

For correspondence:-  Bo Li   Email: bolelee@126.com   Tel:+862062323939

Accepted: 25 November 2019        Published: 30 December 2019

Citation: Wu D, Li B. Protective effect of punicalagin against intracerebral haemorrhage via improvement in blood-brain barrier integrity, and suppression of reactive oxygen species and NF-κB-mediated NLRP3 inflammasome. Trop J Pharm Res 2019; 18(12):2515-2523 doi: 10.4314/tjpr.v18i12.8

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effect of punicalagin in a rodent model of intracerebral haemorrhage (ICH).
Methods: Collagenase type IV (0.2 U) was used to induce ICH in Sprague-Dawley rats. The animals were randomly assigned to 5 treatment groups (n = 24) as follows: group I (normal control animals), group II (ICH control group administered saline), and groups III, IV and V (ICH + punicalagin at doses of 12.5, 25, 50 mg/kg, respectively).
Results: Punicalagin treatment improved brain tissue architecture and blood-brain barrier integrity, and reduced ICH-mediated oxidative stress. It effectively upregulated the expression of Nrf-2/HO-1, and enhanced the activation of NF-kB and NLRP3 inflammasome (p < 0.05). Furthermore, punicalagin significantly down-regulated ICH injury-induced increase in IL-1β and IL-18 (p < 0.05). 
Conclusion: These results suggest that punicalagin is a potential therapeutic candidate for the management of ICH.

Keywords: Blood brain barrier, Inflammation, Intracerebral haemorrhage, Nuclear factor-kappa B, Punicalagin, Reactive oxygen species

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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